Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis in mouse models.
|
15258196 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, validating this hypothesis may clarify the role of PLTP in macrophage ERs in AS and also raise a novel strategy in the regression of AS plaques via restoring intracellular membrane lipid homeostasis and attenuating ERs.
|
28012603 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was performed to relate the increased atherosclerosis in PLTP transgenic mice to one of these atherogenic effects.
|
16935026 |
2006 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phospholipid transfer protein (PLTP) deficiency reduced apo B production in apo E-/- mice, as well as oxidative stress in four models of mouse atherosclerosis.
|
15694928 |
2005 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mice with overexpression of human PLTP have an increased ability to generate pre beta-HDL, reduced total HDL levels and an increased susceptibility to atherosclerosis.
|
19100548 |
2009 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this review, I summarize the major progress made in the PLTP research field and emphasize its impact on lipoprotein metabolism and atherosclerosis, as well as its regulation.
|
29438986 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In low density lipoprotein receptor (LDLR)-deficient mice, overexpression of human plasma phospholipid transfer protein (PLTP) results in increased atherosclerosis.
|
17761633 |
2007 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, acute elevation of PLTP activity destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis.
|
18421000 |
2008 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to its role in lipoprotein metabolism and atherosclerosis, the latest advances came in support of a complex role of PLTP in the regulation of the inflammatory response, both with pro-inflammatory or anti-inflammatory properties.
|
29565987 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, p53 augmented the activity of secreted PLTP, which plays a major role in lipoprotein biology and atherosclerosis pathology.
|
22037227 |
2012 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human PLTP expression in HuPLTPTg rabbit worsens atherosclerosis as a result of increased levels of atherogenic apoB-containing lipoproteins but not of alterations in their antioxidative protection or in cholesterol content of plasma HDL.
|
21252068 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the specific role that PLTP plays in human diseases, such as atherosclerosis, cancer, or neurodegenerative disease, remains to be clarified.
|
21736953 |
2012 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of PLTP has been implicated in the development of atherosclerosis.
|
19965587 |
2010 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential.
|
12086920 |
2002 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity.
|
28596518 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target.
|
31017809 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development; however, little is known about the regulation of PLTP.
|
29680823 |
2018 |